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Liraglutide: (Moderate) Monitor patients receiving antidiabetic agents closely for worsening glycemic control when corticosteroids are instituted and for signs of hypoglycemia when corticosteroids are discontinued. 34 While symptomatic patients shed more HSV viral DNA than asymptomatic patients, the asymptomatic patients are likely the more common source of transmission since there are many more of them. Sûr, effectif, très simple en utilisation.

Whilst the CONSORT guidelines recommend a PP approach (that is, analysis according to actual treatment received) as the conservative non-inferiority analysis option, given the potential biases of both PP and ITT analyses, we agree with the European Agency for the Evaluation of Medicinal Products that security of inference depends on both PP and ITT analyses demonstrating non-inferiority of the primary outcome [ 55]. • Corticosteroids should be used in patients with a definite diagnosis of severe alcoholic hepatitis, who have a discriminant function >32, hepatic encephalopathy, or both.

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